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Results: We screened 39 patients, of whom 37 were enrolled and received at least one dose of nivolumab. There were two complete responses and seven partial responses.
No serious adverse events were reported. Interpretation: To our knowledge, this is the first completed phase 2 trial of immunotherapy for SCCA.
Nivolumab is well tolerated and effective as a monotherapy for patients with metastatic SCCA. Immune checkpoint blockade appears to be a promising approach for patients with this orphan disease.
Muscles anal sphincters that surround the anal canal relax to allow waste to leave your body. Anal cancer is an uncommon type of cancer that occurs in the anal canal.
The anal canal is a short tube at the end of your rectum through which stool leaves your body. Most people with anal cancer are treated with a combination of chemotherapy and radiation.
Though combining anal cancer treatments increases the chance of a cure, the combined treatments also increase the risk of side effects. Talk to your doctor about any signs and symptoms that bother you, especially if you have any factors that increase your risk of anal cancer.
Anal cancer forms when a genetic mutation turns normal, healthy cells into abnormal cells. Healthy cells grow and multiply at a set rate, eventually dying at a set time.
Abnormal cells grow and multiply out of control, and they don't die. The accumulating abnormal cells form a mass tumor.
Cancer cells invade nearby tissues and can separate from an initial tumor to spread elsewhere in the body metastasize. Anal cancer is closely related to a sexually transmitted infection called human papillomavirus HPV.
Evidence of HPV is detected in the majority of anal cancers. HPV is thought to be the most common cause of anal cancers.
Anal cancer rarely spreads metastasizes to distant parts of the body. Only a small percentage of tumors are found to have spread, but those that do are especially difficult to treat.
Anal cancer that metastasizes most commonly spreads to the liver and the lungs. Anal cancer care at Mayo Clinic. Mayo Clinic does not endorse companies or products.
Advertising revenue supports our not-for-profit mission. This content does not have an English version. This content does not have an Arabic version.
Overview The anal canal Open pop-up dialog box Close. Request an Appointment at Mayo Clinic. Share on: Facebook Twitter. Show references Deng GE, et al.
Evidence-based clinical practice guidelines for integrative oncology: Complementary therapies and botanicals.
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At the time of data cutoff, the study was ongoing, with patients continuing to receive treatment.
The study is registered with ClinicalTrials. Results: We screened 39 patients, of whom 37 were enrolled and received at least one dose of nivolumab.
There were two complete responses and seven partial responses. No serious adverse events were reported. Interpretation: To our knowledge, this is the first completed phase 2 trial of immunotherapy for SCCA.
This content does not have an Arabic version. Overview The anal canal Open pop-up dialog box Close. Request an Appointment at Mayo Clinic.
Share on: Facebook Twitter. Show references Deng GE, et al. Evidence-based clinical practice guidelines for integrative oncology: Complementary therapies and botanicals.
Journal of the Society for Integrative Oncology. Anal carcinoma. Plymouth Meeting, Pa. Accessed April 1, Anal cancer treatment PDQ — Health professional version.
National Cancer Institute. Accessed July 5, Gardasil 9 prescribing information. Whitehouse Station, N. Accessed June 2, Niederhuber JE, et al.
Cancer of the anal canal. In: Abeloff's Clinical Oncology. Philadelphia, Pa. Taking time: Support for people with cancer.
Palliative care. Fort Washington, Pa. Accessed May 5, Warner KJ. Allscripts EPSi. Mayo Clinic, Rochester, Minn.
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